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Mepazine hydrochloride
CAS No. 2975-36-2
Mepazine hydrochloride ( —— )
产品货号. M35520 CAS No. 2975-36-2
Mepazine hydrochloride (Pecazine hydrochloride) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine hydrochloride 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的IC50 分别为 0.83 和 0.42 μM。Mepazine hydrochloride 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥315 | 有现货 |
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| 10MG | ￥452 | 有现货 |
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| 25MG | ￥696 | 有现货 |
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| 50MG | ￥1001 | 有现货 |
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| 100MG | ￥1431 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Mepazine hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Mepazine hydrochloride (Pecazine hydrochloride) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine hydrochloride 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的IC50 分别为 0.83 和 0.42 μM。Mepazine hydrochloride 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。
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产品描述Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
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体外实验Cell Viability Assay Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration:5, 10, and 20 μM Incubation Time:4 days Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
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体内实验Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
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同义词——
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通路NF-κB
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靶点MALT1
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受体MALT
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研究领域——
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适应症——
化学信息
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CAS Number2975-36-2
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分子量346.92
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分子式C19H23ClN2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (144.13 mM; 超声助溶 ) H2O 中的溶解度 : 2.22 mg/mL (6.40 mM; 超声助溶 (<60°C))
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SMILESCl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.?
